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LITFULO™ Drug Interactions (ritlecitinib)

7 DRUG INTERACTIONS

     

7.1 Effects of LITFULO on Other Drugs

Table 3 includes clinically significant drug interactions affecting other drugs.

Table 3. Clinically Significant Interactions Affecting Other Drugs

CYP3A Substrates Where Small Concentration Changes May Lead to Serious Adverse Reactions

Clinical Impact

Ritlecitinib is a CYP3A inhibitor. Concomitant use of ritlecitinib increases AUC and Cmax of CYP3A substrates [see Clinical Pharmacology (12.3)], which may increase the risk of adverse reactions of these substrates.

Intervention

Consider additional monitoring and dosage adjustment in accordance with approved product labeling of CYP3A substrates where small concentration changes may lead to serious adverse reactions when used with LITFULO.

CYP1A2 Substrates Where Small Concentration Changes May Lead to Serious Adverse Reactions

Clinical Impact

Ritlecitinib is a CYP1A2 inhibitor. Concomitant use of ritlecitinib increases AUC and Cmax of CYP1A2 substrates [see Clinical Pharmacology (12.3)], which may increase the risk of adverse reactions of these substrates.

Intervention

Consider additional monitoring and dosage adjustment in accordance with the approved product labeling of CYP1A2 substrates where small concentration changes may lead to serious adverse reactions when used concomitantly with LITFULO.

7.2 Effects of Other Drugs on LITFULO

Table 4 includes clinically significant drug interactions affecting LITFULO.

Table 4. Clinically Significant Interactions Affecting LITFULO

CYP3A Inducers

Clinical Impact

Concomitant use of strong CYP3A inducer (e.g., rifampin) may decrease AUC and Cmax of ritlecitinib [see Clinical Pharmacology (12.3)], which may result in loss of or reduced clinical response.

Intervention

Coadministration with strong inducers of CYP3A is not recommended.

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