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labetalol Hydrochloride Injection, USP - VIAL

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labetalol Hydrochloride Injection, USP - VIAL Quick Finder

INDICATIONS AND USAGE

Labetalol HCl injection is indicated for control of blood pressure in severe hypertension.

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DOSAGE AND ADMINISTRATION

Labetalol hydrochloride injection is intended for intravenous use in hospitalized patients. DOSAGE MUST BE INDIVIDUALIZED depending upon the severity of hypertension and the response of the patient...

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CONTRAINDICATIONS

Labetalol HCl injection is contraindicated in bronchial asthma, overt cardiac failure, greater than first degree heart block, cardiogenic shock, severe bradycardia, other conditions associated with severe...

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WARNINGS

Hepatic Injury

Severe hepatocellular injury, confirmed by rechallenge in at least one case, occurs rarely with labetalol therapy. The hepatic injury is...

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ADVERSE REACTIONS

Labetalol injection is usually well tolerated. Most adverse effects have been mild and transient and in controlled trials involving 92 patients did not require labetalol withdrawal. Symptomatic postural...

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OVERDOSAGE

Overdosage with labetalol injection causes excessive hypotension that is posture sensitive, and sometimes, excessive bradycardia. Patients should be placed supine and their legs raised if necessary to improve the...

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DESCRIPTION

Labetalol hydrochloride is an adrenergic receptor blocking agent that has both selective alpha1- and nonselective beta-adrenergic receptor blocking actions in a single substance.

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CLINICAL PHARMACOLOGY

Labetalol combines both selective, competitive alpha1-adrenergic blocking and nonselective, competitive beta-adrenergic blocking activity in a single substance. In man, the ratios of alpha- to beta-...

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HOW SUPPLIED

Labetalol hydrochloride injection, USP 5 mg/mL, is supplied in:

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Injection, USP

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