IBRANCE (palbociclib) Recommended Dose Modifications for Adverse Reactions

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Adverce Events from CTCAE: 
Anemia
Febrile neutropenia
Blood and lymphatic system disorders - Other
Blurred vision
Conjunctivitis
Dry eye
Watering eyes
Abdominal pain
Constipation
Diarrhea
Mucositis oral
Nausea
Vomiting
Gastrointestinal disorders - Other
Fatigue
Fever
Bronchial infection
Conjunctivitis infective
Corneal infection
Enterocolitis infectious
Eye infection
Laryngitis
Lung infection
Nail infection
Papulopustular rash
Paronychia
Periorbital infection
Pharyngitis
Rash pustular
Rhinitis infective
Sinusitis
Skin infection
Tooth infection
Upper respiratory infection
Urinary tract infection
Infections and infestations - Other
Alanine aminotransferase increased
Alkaline phosphatase increased
Aspartate aminotransferase increased
Blood bilirubin increased
Electrocardiogram QT corrected interval prolonged
Hemoglobin increased
Lymphocyte count decreased
Neutropenia
Thrombocytopenia
Leukopenia
Anorexia
Generalized muscle weakness
Dysgeusia
Headache
Epistaxis
Alopecia
Rash acneiform
Rash maculo-papular
Arthralgia
Arthritis
Infections
Rash
Skin and subcutaneous tissue disorders - Other
Malaise
Pneumonitis
Dry skin
Product: 
IBRANCE (en-us): IBRANCE® capsules (palbociclib)
Top block: 

This tool was designed to help you assess the grade of the adverse event reported by your patient and to get dosing modifications recommendations based on the grade of the event as per the approved IBRANCE Prescribing Information.

  • Step 1: select an adverse event (see most common adverse reactions below, please use our search functionality or switch to view the full list)
  • Step 2: assess the grade of the adverse event as per CTCAE 4.0 criteria
  • Step 3: determine appropriate dosing modifications strategies

If you need additional information (including the incidence of the adverse events occurring in the pivotal palbociclib randomized clinical trials), please consult the approved IBRANCE Prescribing Information, search through our collection of approved scientific response documents or contact us directly (submit a request online, call 1-800-438-1985, or chat).

Most common AE: 
Neutropenia
Leukopenia
Anemia
Thrombocytopenia
Infections
Nausea
Diarrhea
Vomiting
Mucositis oral
Anorexia
Alopecia
Dry skin
Rash
Fatigue
Malaise
Fever
Recommended Dose Modifications: 
IBRANCE tool - Dose Modification – Hematologic Toxicities
IBRANCE tool - Dose Modification – Neutropenia
IBRANCE tool - Dose Modification – Non-Hematologic Toxicities