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IBRANCE (palbociclib) Recommended Dose Modifications for Adverse Reactions

This tool was designed to help you assess the grade of the adverse event reported by your patient and to get dosing modifications recommendations based on the grade of the event as per the approved IBRANCE Prescribing Information.

  • Step 1: select an adverse event (see most common adverse reactions below, please use our search functionality or switch to view the full list)
  • Step 2: assess the grade of the adverse event as per CTCAE 4.0 criteria
  • Step 3: determine appropriate dosing modifications strategies

If you need additional information (including the incidence of the adverse events occurring in the pivotal palbociclib randomized clinical trials), please consult the approved IBRANCE Prescribing Information, search through our collection of approved scientific response documents or contact us directly (submit a request online, call 1-800-438-1985, or chat).

Most Common Adverse Reactions (View all)
All Adverse Reactions (View most common)
Search result
Blood and lymphatic system disorders
Neutropenia
Neutrophil count decreased
A finding based on laboratory test results that indicate a decrease in number of neutrophils in a blood specimen.
Leukopenia
White blood cell decreased
A finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen.
Anemia
Anemia
A disorder characterized by an reduction in the amount of hemoglobin in 100 ml of blood. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability.
Thrombocytopenia
Platelet count decreased
A finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen.
Gastrointestinal disorders
Nausea
Nausea
A disorder characterized by a queasy sensation and/or the urge to vomit.
Diarrhea
Diarrhea
A disorder characterized by frequent and watery bowel movements.
Vomiting
Vomiting
A disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth.
Mucositis oral
Mucositis oral
A disorder characterized by inflammation of the oral mucosal.
General disorders and administration site conditions
Fatigue
Fatigue
A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities.
Malaise
Malaise
A disorder characterized by a feeling of general discomfort or uneasiness, an out-of-sorts feeling.
Fever
Fever
A disorder characterized by elevation of the body's temperature above the upper limit of normal.
Infections and infestations
Infections
Metabolism and nutrition disorders
Anorexia
Anorexia
A disorder characterized by a loss of appetite.
Skin and subcutaneous tissue disorders
Alopecia
Alopecia
A disorder characterized by a decrease in density of hair compared to normal for a given individual at a given age and body location.
Dry skin
Dry skin
A disorder characterized by flaky and dull skin; the pores are generally fine, the texture is a papery thin texture.
Rash
Skin and subcutaneous tissue disorders - Other
Skin and subcutaneous tissue disorders - Other, specify
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Blood and lymphatic system disorders
Anemia
Anemia
A disorder characterized by an reduction in the amount of hemoglobin in 100 ml of blood. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability.
Febrile neutropenia
Febrile neutropenia
A disorder characterized by an ANC <1000/mm3 and a single temperature of >38.3 degrees C (101 degrees F) or a sustained temperature of >=38 degrees C (100.4 degrees F) for more than one hour
Neutropenia
Neutrophil count decreased
A finding based on laboratory test results that indicate a decrease in number of neutrophils in a blood specimen.
Thrombocytopenia
Platelet count decreased
A finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen.
Leukopenia
White blood cell decreased
A finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen.
Blood and lymphatic system disorders - Other
Blood and lymphatic system disorders - Other, specify
Eye disorders
Blurred vision
Blurred vision
A disorder characterized by visual perception of unclear or fuzzy images.
Conjunctivitis
Conjunctivitis
A disorder characterized by inflammation, swelling and redness to the conjunctiva of the eye.
Dry eye
Dry eye
A disorder characterized by dryness of the cornea and conjunctiva.
Watering eyes
Watering eyes
A disorder of excessive tearing in the eyes; it can be caused by overproduction of tears or impaired drainage of the tear duct.
Gastrointestinal disorders
Abdominal pain
Abdominal pain
A disorder characterized by a sensation of marked discomfort in the abdominal region.
Constipation
Constipation
A disorder characterized by irregular and infrequent or difficult evacuation of the bowels.
Diarrhea
Diarrhea
A disorder characterized by frequent and watery bowel movements.
Mucositis oral
Mucositis oral
A disorder characterized by inflammation of the oral mucosal.
Nausea
Nausea
A disorder characterized by a queasy sensation and/or the urge to vomit.
Vomiting
Vomiting
A disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth.
Gastrointestinal disorders - Other
Gastrointestinal disorders - Other, specify
General disorders and administration site conditions
Fatigue
Fatigue
A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities.
Fever
Fever
A disorder characterized by elevation of the body's temperature above the upper limit of normal.
Malaise
Malaise
A disorder characterized by a feeling of general discomfort or uneasiness, an out-of-sorts feeling.
Infections and infestations
Bronchial infection
Bronchial infection
A disorder characterized by an infectious process involving the bronchi.
Conjunctivitis infective
Conjunctivitis infective
A disorder characterized by an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes.
Corneal infection
Corneal infection
A disorder characterized by an infectious process involving the cornea.
Enterocolitis infectious
Enterocolitis infectious
A disorder characterized by an infectious process involving the small and large intestines.
Eye infection
Eye infection
A disorder characterized by an infectious process involving the eye.
Laryngitis
Laryngitis
A disorder characterized by an inflammatory process involving the larynx.
Lung infection
Lung infection
A disorder characterized by an infectious process involving the lungs.
Nail infection
Nail infection
A disorder characterized by an infectious process involving the nail.
Paronychia
Paronychia
A disorder characterized by an infectious process involving the soft tissues around the nail.
Periorbital infection
Periorbital infection
A disorder characterized by an infectious process involving the orbit of the eye.
Pharyngitis
Pharyngitis
A disorder characterized by inflammation of the throat.
Rhinitis infective
Rhinitis infective
A disorder characterized by an infectious process involving the nasal mucosal.
Sinusitis
Sinusitis
A disorder characterized by an infectious process involving the mucous membranes of the paranasal sinuses.
Skin infection
Skin infection
A disorder characterized by an infectious process involving the skin.
Tooth infection
Tooth infection
A disorder characterized by an infectious process involving a tooth.
Upper respiratory infection
Upper respiratory infection
A disorder characterized by an infectious process involving the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea).
Urinary tract infection
Urinary tract infection
A disorder characterized by an infectious process involving the urinary tract, most commonly the bladder and the urethra.
Infections and infestations - Other
Infections and infestations - Other, specify
Investigations
Alanine aminotransferase increased
Alanine aminotransferase increased
A finding based on laboratory test results that indicate an increase in the level of alanine aminotransferase (ALT or SGPT) in the blood specimen.
Alkaline phosphatase increased
Alkaline phosphatase increased
A finding based on laboratory test results that indicate an increase in the level of alkaline phosphatase in a blood specimen.
Aspartate aminotransferase increased
Aspartate aminotransferase increased
A finding based on laboratory test results that indicate an increase in the level of aspartate aminotransferase (AST or SGOT) in a blood specimen.
Blood bilirubin increased
Blood bilirubin increased
A finding based on laboratory test results that indicate an abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice.
Electrocardiogram QT corrected interval prolonged
Electrocardiogram QT corrected interval prolonged
A finding of a cardiac dysrhythmia characterized by an abnormally long corrected QT interval.
Hemoglobin increased
Hemoglobin increased
A finding based on laboratory test results that indicate increased levels of hemoglobin in a biological specimen.
Lymphocyte count decreased
Lymphocyte count decreased
A finding based on laboratory test results that indicate a decrease in number of lymphocytes in a blood specimen.
Metabolism and nutrition disorders
Anorexia
Anorexia
A disorder characterized by a loss of appetite.
Musculoskeletal and connective tissue disorders
Generalized muscle weakness
Generalized muscle weakness
A disorder characterized by a reduction in the strength of muscles in multiple anatomic sites.
Arthralgia
Arthralgia
A disorder characterized by a sensation of marked discomfort in a joint.
Arthritis
Arthritis
A disorder characterized by inflammation involving a joint.
Nervous system disorders
Dysgeusia
Dysgeusia
A disorder characterized by abnormal sensual experience with the taste of foodstuffs; it can be related to a decrease in the sense of smell.
Headache
Headache
A disorder characterized by a sensation of marked discomfort in various parts of the head, not confined to the area of distribution of any nerve.
Respiratory, thoracic and mediastinal disorders
Epistaxis
Epistaxis
A disorder characterized by bleeding from the nose.
Skin and subcutaneous tissue disorders
Papulopustular rash
Papulopustular rash
A disorder characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back Unlike acne, this rash does not present with whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions.
Rash pustular
Rash pustular
A disorder characterized by a circumscribed and elevated skin lesion filled with pus.
Alopecia
Alopecia
A disorder characterized by a decrease in density of hair compared to normal for a given individual at a given age and body location.
Dry skin
Dry skin
A disorder characterized by flaky and dull skin; the pores are generally fine, the texture is a papery thin texture.
Rash acneiform
Rash acneiform
A disorder characterized by an eruption of papules and pustules, typically appearing in face, scalp, upper chest and back.
Rash maculo-papular
Rash maculo-papular
A disorder characterized by the presence of macules (flat) and papules (elevated). Also known as morbillform rash, it is one of the most common cutaneous adverse events, frequently affecting the upper trunk, spreading centripetally and associated with pruritis.
Skin and subcutaneous tissue disorders - Other
Skin and subcutaneous tissue disorders - Other, specify
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