WARNING: MORTALITY; KIDNEY INJURY; COAGULOPATHY
- Use of hydroxyethyl starch (HES) products, including HEXTEND, increases risk of
- Mortality
- Kidney...
Did you find an answer to your question?
Yes
No
If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents.
Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.
HEXTEND (6% Hetastarch in Lactated Electrolyte Injection)
If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents.
Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.
HEXTEND Quick Finder
Boxed Warning
Indications and Usage
INDICATIONS AND USAGE
HEXTEND (6% Hetastarch in Lactated Electrolyte Injection) is indicated in the treatment of hypovolemia when plasma volume expansion is desired in settings where adequate alternative treatment is...
Did you find an answer to your question?
Yes
No
Dosage and Administration
DOSAGE AND ADMINISTRATION
Dosage for Acute Use in Plasma Volume Expansion
HEXTEND is administered by intravenous infusion only. Total dosage and rate of infusion...
Did you find an answer to your question?
Yes
No
Contraindications
CONTRAINDICATIONS
Do not use HES products, including HEXTEND, unless adequate alternative treatment is unavailable.
Did you find an answer to your question?
Yes
No
Warnings and Precautions
WARNINGS AND PRECAUTIONS
- Increased risk of mortality and acute kidney injury (AKI) in critically ill patients, including patients with sepsis; surgical patients; and blunt trauma patients
- Avoid use in patients...
Did you find an answer to your question?
Yes
No
Adverse Reactions
ADVERSE REACTIONS
Serious adverse reactions reported in postmarketing clinical trials include increased mortality and AKI (including need for RRT) in critically ill subjects, including subjects with sepsis, and surgical...
Did you find an answer to your question?
Yes
No
Clinical Pharmacology
CLINICAL PHARMACOLOGY
The plasma volume expansion produced by HEXTEND approximates that produced by 6% Hetastarch in 0.9% Sodium Chloride Injection and the plasma volume expansion of 6% Hetastarch in 0.9% Sodium Chloride...
Did you find an answer to your question?
Yes
No
Clinical Studies
CLINICAL STUDIES
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another...
Did you find an answer to your question?
Yes
No
How Supplied/Storage and Handling
HOW SUPPLIED
HEXTEND (6% Hetastarch in Lactated Electrolyte Injection) is supplied sterile and nonpyrogenic in 500 mL single-dose flexible plastic infusion containers.
Did you find an answer to your question?
Yes
No
Did you find an answer to your question?
Yes
No
Report Adverse Event
To report an adverse event related to a Pfizer product and you are not part of a clinical trial* for this product, click the link below to submit your information: Pfizer Safety Reporting Site
*If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site.
If you cannot use the above website to report an adverse event related to a Pfizer product, please call Pfizer Medical Information at (800) 438-1985.
You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatchor by calling
(800)-332-1088.
(800)-332-1088.