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furosemide injection, USP ANSYR Adverse Reactions

Adverse Reactions

Adverse reactions are categorized below by organ system and listed by decreasing severity.

 
Gastrointestinal System Reactions
1.
Hepatic encephalopathy in patients with hepatocellular insufficiency
 
7. Cramping
2.
Pancreatitis
 
8. Diarrhea
3.
Jaundice (intrahepatic cholestatic jaundice)
 
9. Constipation
4.
Increased liver enzymes
 
10. Nausea
5.
Anorexia
 
11. Vomiting
6.
Oral and gastric irritation
 
Systemic Hypersensitivity Reactions
1.
Severe anaphylactic or anaphylactoid reactions (e.g. with shock)
 
3. Interstitial nephritis
2.
Systemic vasculititis
 
4. Necrotizing angiitis
 
Central Nervous System Reactions
1.
Tinnitus and hearing loss
 
5. Headache
2.
Paresthesias
 
6 Blurred Vision
3.
Vertigo
 
7 Xanthopsia
4.
Dizziness
 
Hematologic Reactions
1.
Aplastic anemia
 
5. Leukopenia
2.
Thrombocytopenia
 
6. Anemia
3.
Agranulocytosis
 
7. Eosinophilia
4.
Hemolytic anemia
 
Dermatologic-Hypersensitivity Reactions
1.
Exfoliative dermatitis
 
6. Urticaria
2.
Bullous pemphigoid
 
7. Rash
3.
Erythema multiforme
 
8. Pruritus
4.
Purpura
 
9. Stevens-Johnson Syndrome
5.
Photosensitivity
 
10. Toxic epidermal necrolysis
 
Cardiovascular Reactions
 
1. Orthostatic hypotension may occur and be aggravated by alcohol, barbiturates or narcotics
 
2.  Increase in cholesterol and triglyceride serum levels
 
Other Reactions
 
1. Hyperglycemia
 
6. Restlessness
 
2. Glycosuria
 
7. Urinary bladder spasm
 
3. Hyperuricemia
 
8. Thrombophlebitis
 
4. Muscle spasms
 
9. Transient injection site pain following intramuscular injection
 
5. Weakness
 
10. Fever

Whenever adverse reactions are moderate or severe, furosemide dosage should be reduced or therapy withdrawn.

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