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fludarabine phosphate for injection, USP Overdosage

OVERDOSAGE

High doses of fludarabine phosphate, USP (see WARNINGS section) have been associated with an irreversible central nervous system toxicity characterized by delayed blindness, coma, and death. High doses are also associated with severe thrombocytopenia and neutropenia due to bone marrow suppression. There is no known specific antidote for fludarabine phosphate, USP overdosage. Treatment consists of drug discontinuation and supportive therapy.

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