WARNINGS: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER AND PROBABLE DEMENTIA
Estrogen-Alone Therapy
...
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ESTRING® (estradiol)
If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents.
Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.
ESTRING® Quick Finder
Indications and Usage
INDICATIONS AND USAGE
ESTRING is indicated for the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.
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Dosage and Administration
DOSAGE AND ADMINISTRATION
One ESTRING (estradiol vaginal system) is to be inserted as deeply as possible into the upper one-third of the vaginal vault. The ring is to remain in place continuously for three months, after...
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Contraindications
CONTRAINDICATIONS
ESTRING is contraindicated in women with any of the following conditions:
- 1.
- Undiagnosed abnormal genital bleeding.
- 2.
- Known, suspected, or history of breast cancer. ...
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Warnings and Precautions
WARNINGS
See BOXED WARNINGS
ESTRING is a vaginal administered product with low systemic absorption following continuous use for 3 months (see CLINICAL...
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Adverse Reactions
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Overdosage
OVERDOSAGE
Overdosage of estrogen may cause nausea, vomiting, breast tenderness, abdominal pain, drowsiness and fatigue, and withdrawal bleeding may occur in women. Treatment of overdose consists of discontinuation of...
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Description
DESCRIPTION
ESTRING® (estradiol vaginal system) is a slightly opaque ring with a whitish core containing a drug reservoir of 2 mg estradiol. Estradiol, silicone polymers, barium sulfate and silicone...
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Clinical Pharmacology
CLINICAL PHARMACOLOGY
Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic...
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Clinical Studies
CLINICAL STUDIES
Effects on vulvar and vaginal atrophy
Two controlled studies have demonstrated the efficacy of ESTRING (estradiol vaginal system) in the treatment of...
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How Supplied/Storage and Handling
HOW SUPPLIED
Each ESTRING (estradiol vaginal system) contains 2 mg estradiol to deliver 7.5 mcg of estradiol per day over 90 days, and is individually packaged in a heat-sealed rectangular pouch consisting of three layers,...
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Medication Guide
PATIENT INFORMATION
ESTRING
(estradiol vaginal system)
Read this Patient Information before you start using ESTRING and each time you get a refill. There may be...
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Instructions For Use
INSTRUCTIONS FOR USE
How should I use ESTRING?
ESTRING is a local estrogen therapy used after menopause to treat moderate to severe menopausal changes in and around the vagina. ESTRING...
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Resources
Report Adverse Event
To report an adverse event related to a Pfizer product and you are not part of a clinical trial* for this product, click the link below to submit your information: Pfizer Safety Reporting Site
*If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site.
If you cannot use the above website to report an adverse event related to a Pfizer product, please call Pfizer Medical Information at (800) 438-1985.
You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatchor by calling
(800)-332-1088.
(800)-332-1088.