2 DOSAGE AND ADMINISTRATION
2.1 Recommended Dosage in Adults
The recommended dose is a single 200 mg loading dose of ERAXIS on Day 1, followed by a 100 mg once daily maintenance dose thereafter. Duration of treatment should be based on the patient's clinical response. In general, antifungal therapy should continue for at least 14 days after the last positive culture.
The recommended dose is a single 100 mg loading dose of ERAXIS on Day 1, followed by a 50 mg once daily maintenance dose thereafter. Patients should be treated for a minimum of 14 days and for at least 7 days following resolution of symptoms. Duration of treatment should be based on the patient's clinical response. Because of the risk of relapse of esophageal candidiasis in patients with HIV infection, suppressive antifungal therapy may be considered after a course of treatment.
2.4 Dilution and Administration of the Infusion
|Dose||Number of Vials Required||Total Reconstituted Volume Required||Infusion Volume*||Total Infusion Volume†||Rate of Infusion||Minimum Duration of Infusion|
|50 mg||1–50 mg||15 mL||50 mL||65 mL||1.4 mL/min or 84 mL/ hour||45 min|
|100 mg||2–50 mg or 1–100 mg||30 mL||100 mL||130 mL||1.4 mL/min or 84 mL/ hour||90 min|
|200 mg||4–50 mg or 2–100 mg||60 mL||200 mL||260 mL||1.4 mL/min or 84 mL/ hour||180 min|