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EPINEPHRINE ABBOJECT NDC 0409-4933-01 Drug Interactions (Epinephrine injection, USP ABBOJECT)

7 DRUG INTERACTIONS

7.1 Drugs Antagonizing Pressor Effects of Epinephrine

  • α-blockers, such as phentolamine
  • Vasodilators, such as nitrates
  • Diuretics
  • Antihypertensives
  • Ergot alkaloids
  • Phenothiazine antipsychotics

7.2 Drugs Potentiating Pressor Effects of Epinephrine

  • Sympathomimetics
  • β-blockers, such as propranolol
  • Tricyclic anti-depressants
  • Monoamine oxidase (MAO) inhibitors
  • Catechol-O-methyl transferase (COMT) inhibitors, such as entacapone
  • Clonidine
  • Doxapram
  • Oxytocin

7.3 Drugs Potentiating Arrhythmogenic Effects of Epinephrine

Patients who are concomitantly receiving any of the following drugs should be observed carefully for the development of cardiac arrhythmias [see Warnings and Precautions (5.5) and Adverse Reactions (6)].

  • β-blockers, such as propranolol
  • Cyclopropane or halogenated hydrocarbon anesthetics, such as halothane
  • Antihistamines
  • Thyroid hormones
  • Diuretics
  • Cardiac glycosides, such as digitalis glycosides
  • Quinidine

7.4 Drugs Potentiating Hypokalemic Effects of Epinephrine

  • Potassium depleting diuretics
  • Corticosteroids
  • Theophylline
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