4 CONTRAINDICATIONS
DUAVEE is contraindicated in women with any of the following conditions:
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- Undiagnosed abnormal uterine bleeding
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- Known, suspected, or past history of breast cancer
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- Known or suspected estrogen-dependent neoplasia
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- Active deep venous thrombosis, pulmonary embolism, or history of these conditions
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- Active arterial thromboembolic disease (for example, stroke, myocardial infarction) or history of these conditions
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- Hypersensitivity (for example, anaphylaxis, angioedema) to estrogens, bazedoxifene, or any ingredients
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- Known hepatic impairment or disease
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- Known protein C, protein S, or antithrombin deficiency or other known thrombophilic disorders
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- Pregnancy, as DUAVEE may cause fetal harm [see pregnancy (8.1)].