4 CONTRAINDICATIONS
DUAVEE is contraindicated in women with any of the following conditions:
- Undiagnosed abnormal uterine bleeding
- Known, suspected, or past history of breast cancer
- Known or suspected estrogen-dependent neoplasia
- Active deep venous thrombosis, pulmonary embolism, or history of these conditions
- Active arterial thromboembolic disease (for example, stroke, myocardial infarction) or history of these conditions
- Hypersensitivity (for example, anaphylaxis, angioedema) to estrogens, bazedoxifene, or any ingredients
- Known hepatic impairment or disease
- Known protein C, protein S, or antithrombin deficiency or other known thrombophilic disorders
- Pregnancy, as DUAVEE may cause fetal harm [see pregnancy (8.1)].