4 CONTRAINDICATIONS
Doxorubicin Hydrochloride Injection/for Injection are contraindicated in patients with:
- Severe myocardial insufficiency [see Warnings and Precautions (5.1)]
- Recent (occurring within the past 4–6 weeks) myocardial infarction [see Warnings and Precautions (5.1)]
- Severe persistent drug-induced myelosuppression [see Warnings and Precautions (5.4)]
- Severe hepatic impairment (defined as Child Pugh Class C or serum bilirubin level greater than 5 mg/dL) [see Warnings and Precautions (5.5)]
- Severe hypersensitivity reaction to doxorubicin hydrochloride, including anaphylaxis [see Adverse Reactions (6.2)]