11 DESCRIPTION
Depo-subQ provera 104 contains medroxyprogesterone acetate (MPA), a derivative of progesterone, as its active ingredient. MPA is a white to off-white, odorless crystalline powder that is stable in air and that melts between 205°C and 209°C. It is freely soluble in chloroform, soluble in acetone and dioxane, sparingly soluble in alcohol and methanol, slightly soluble in ether, and insoluble in water.
The chemical name for MPA is 17-hydroxy-6α-methylpregn-4-ene-3,20-dione 17-acetate. The structural formula is as follows:
Depo-subQ provera 104 for subcutaneous use is available in pre-filled syringes, each containing 0.65 mL (104 mg) of sterile medroxyprogesterone acetate injectable suspension.
Each 0.65 mL contains the following inactive ingredients:
| Methylparaben | 1.040 mg |
| Propylparaben | 0.098 mg |
| Sodium Chloride | 5.200 mg |
| Polyethylene Glycol | 18.688 mg |
| Polysorbate 80 | 1.950 mg |
| Monobasic Sodium Phosphate H2O | 0.451 mg |
| Dibasic Sodium Phosphate 12H2O | 0.382 mg |
| Methionine | 0.975 mg |
| Povidone | 3.250 mg |
| Water for Injection | qs |
When necessary, the pH is adjusted with sodium hydroxide or hydrochloric acid, or both.