DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL, 40 mg/mL, 80 mg/mL.
Each mL of these preparations contains:
|Methylprednisolone acetate||20 mg||40 mg||80 mg|
|Polyethylene glycol 3350||29.5 mg||29.1 mg||28.2 mg|
|Polysorbate 80||1.97 mg||1.94 mg||1.88 mg|
|Monobasic sodium phosphate||6.9 mg||6.8 mg||6.59 mg|
|Dibasic sodium phosphate USP||1.44 mg||1.42 mg||1.37 mg|
|Benzyl alcohol added as a preservative||9.3 mg||9.16 mg||8.88 mg|
Sodium Chloride was added to adjust tonicity.
When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.
The pH of the finished product remains within the USP specified range (e.g., 3.5 to 7.0).
The chemical name for methylprednisolone acetate is pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-,(6α,11ß)- and the molecular weight is 416.51. The structural formula is represented below:
DEPO-MEDROL Sterile Aqueous Suspension contains methylprednisolone acetate which is the 6-methyl derivative of prednisolone. Methylprednisolone acetate is a white or practically white, odorless, crystalline powder which melts at about 215° with some decomposition. It is soluble in dioxane, sparingly soluble in acetone, alcohol, chloroform, and methanol, and slightly soluble in ether. It is practically insoluble in water.