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DEMEROL Nonclinical Toxicology (Meperidine Hydrochloride Injection, USP)

13 NONCLINICAL TOXICOLOGY

13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility

Carcinogenesis

Long-term studies in animals to evaluate the carcinogenic potential of meperidine have not been conducted.

Mutagenesis

Studies in animals to evaluate the mutagenic potential of meperidine have not been conducted.

Impairment of Fertility

Studies to determine the effect of meperidine on fertility have not been conducted.

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