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DEMEROL Description (Meperidine Hydrochloride Injection, USP)

11 DESCRIPTION

DEMEROL (meperidine hydrochloride, USP) Injection is an opioid agonist, available for intramuscular, intravenous, or subcutaneous administration. The chemical name is 4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-,ethyl ester, hydrochloride. The molecular weight is 283,80. Its molecular formula is C15H21NO2∙HCl, and it has the following chemical structure.

Chemical Structure

Meperidine hydrochloride is a white crystalline substance with a melting point of 186° C to 189° C. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution is not decomposed by a short period of boiling.

DEMEROL INJECTION is available as Injectable for subcutaneous, intramuscular, or intravenous use, Carpuject Single-dose cartridge with Luer Lock for the Carpuject Syringe System: 25 mg/mL, 50 mg/mL, 75 mg/mL, and 100 mg/mL. Each mL of single-dose cartridge contains 25 mg, 50 mg, 75 mg or 100 mg of meperidine hydrochloride (equivalent to 21.79 mg, 43.58 mg, 65.36 mg or 87.15 mg of meperidine respectively), sodium chloride for isotonicity (only for the 25 mg), sodium hydroxide, and hydrochloric acid for pH adjustment, in water for injection.

Injectable, multiple-dose vials for subcutaneous, intramuscular, or intravenous use: 1,500 mg/30 mL (50 mg/mL) and 2,000 mg/20 mL (100 mg/mL). Each mL of vial contains 50 mg or 100 mg of meperidine hydrochloride (equivalent to 43.58 mg or 87.15 mg of meperidine respectively), 0.1% metacresol as a preservative, sodium hydroxide, and hydrochloric acid for pH adjustment, in water for injection.

Injectable for subcutaneous, intramuscular, or intravenous use, NexJect™ Single-dose Prefilled Syringe with Luer Lock: 25 mg/mL, 50 mg/mL, 75 mg/mL, and 100 mg/mL. Each mL contains 25 mg, 50 mg or 75 mg or 100 mg of meperidine hydrochloride (equivalent to 21.79 mg, 43.58 mg, 65.36 mg or 87.15 mg of meperidine respectively), sodium chloride for isotonicity (only for the 25 mg), sodium hydroxide, and hydrochloric acid for pH adjustment, in water for injection.

The pH of DEMEROL Injection solutions is adjusted between 3.5 and 6 with sodium hydroxide or hydrochloric acid.

DEMEROL Injection, brand of meperidine hydrochloride, 5 percent solution has a specific gravity of 1.0086 at 20°C and 10 percent solution, a specific gravity of 1.0165 at 20°C.

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