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DAURISMO™ (glasdegib) Patient Counseling Information


Advise the patient to read the FDA-approved patient labeling (Medication Guide).

Advise patients of the risks of DAURISMO treatment:

Embryo-Fetal Toxicity

  • Advise female patients of the potential risk to a fetus and to inform their healthcare provider of a known or suspected pregnancy. Advise female patients and female partners of male patients to contact their healthcare provider with a known or suspected pregnancy [see Warnings and Precautions (5.1), Use in Specific Populations (8.1, 8.3)].

Females and Males of Reproductive Potential

  • Advise females of reproductive potential to use effective contraception during treatment with DAURISMO and for at least 30 days after the last dose.
  • Advise males of the potential risk of exposure through semen and to use effective contraception, including a condom, even after a vasectomy, to avoid drug exposure to a pregnant partner or a female partner of reproductive potential during treatment with DAURISMO and for at least 30 days after the last dose [see Use in Specific Populations (8.3)].

Semen Donation


Blood Donation

  • Advise patients not to donate blood or blood products during treatment with DAURISMO and for at least 30 days after the last dose of DAURISMO [see Warnings and Precautions (5.1)].


QT Interval Prolongation

  • Inform patients of signs and symptoms that may be indicative of significant QT interval prolongation. Advise patients to contact their healthcare provider immediately in the event of syncope, pre-syncopal symptoms, and cardiac palpitations [see Warnings and Precautions (5.2)].

What's New

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