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DACARBAZINE Boxed Warning (dacarbazine for injection, USP)


It is recommended that Dacarbazine for Injection be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.

Hemopoietic depression is the most common toxicity with Dacarbazine for Injection (see WARNINGS).
Hepatic necrosis has been reported (see WARNINGS).
Studies have demonstrated this agent to have a carcinogenic and teratogenic effect when used in animals.
In treatment of each patient, the physician must weigh carefully the possibility of achieving therapeutic benefit against the risk of toxicity.
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