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There is no antidote for cytarabine overdosage. Doses of 4.5 g/m2 by intravenous infusion over 1 hour every 12 hours for 12 doses has caused an unacceptable increase in irreversible CNS toxicity and death.
Single doses as high as 3 g/m2 have been administered by rapid intravenous infusion without apparent toxicity.
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