OVERDOSAGE
There is no antidote for cytarabine overdosage. Doses of 4.5 g/m2 by intravenous infusion over 1 hour every 12 hours for 12 doses has caused an unacceptable increase in irreversible CNS toxicity and death.
Single doses as high as 3 g/m2 have been administered by rapid intravenous infusion without apparent toxicity.