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CORVERT®(ibutilide fumarate)

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CORVERT® Quick Finder

LIFE-THREATENING ARRHYTHMIAS—APPROPRIATE TREATMENT ENVIRONMENT

CORVERT can cause potentially fatal arrhythmias, particularly sustained polymorphic ventricular tachycardia, usually in...

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INDICATIONS AND USAGE

CORVERT Injection is indicated for the rapid conversion of atrial fibrillation or atrial flutter of recent onset to sinus rhythm. Patients with atrial arrhythmias of longer duration are less likely to...

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DOSAGE AND ADMINISTRATION

The recommended dose based on controlled trials (see

Dilution

CORVERT Injection may be administered undiluted or diluted in 50 mL of diluent. CORVERT may be added to 0.9...

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CONTRAINDICATIONS

CORVERT Injection is contraindicated in patients who have previously demonstrated hypersensitivity to ibutilide fumarate or any of the other product components.

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WARNINGS

Proarrhythmia

Like other antiarrhythmic agents, CORVERT Injection can induce or worsen ventricular arrhythmias in some patients. This may have potentially...

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ADVERSE REACTIONS

CORVERT Injection was generally well tolerated in clinical trials. Of the 586 patients with atrial fibrillation or atrial flutter who received CORVERT in phase II/III studies, 149 (25%) reported medical...

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OVERDOSAGE

Acute Experience in Animals

Acute overdose in animals results in CNS toxicity; notably, CNS depression, rapid gasping breathing, and convulsions. The...

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DESCRIPTION

CORVERT Injection (ibutilide fumarate injection) is an antiarrhythmic drug with predominantly class III (cardiac action potential prolongation) properties according to the Vaughan Williams Classification. Each...

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CLINICAL PHARMACOLOGY

Mechanism of Action

CORVERT Injection prolongs action potential duration in isolated adult cardiac myocytes and increases both atrial and...

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HOW SUPPLIED

CORVERT Injection (ibutilide fumarate injection) is supplied as an acetate-buffered isotonic solution at a concentration of 0.1 mg/mL that has been adjusted to approximately pH 4.6 in 10 mL clear glass, single-...

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For intravenous infusion only

Rx only

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