Medical Information
United States
 

In order to provide you with relevant and meaningful content we need to know more about you.

Please choose the category that best describes you.

This content is intended for U.S. Healthcare Professionals. Would you like to proceed?

If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents.

Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.
Not a healthcare professional? Go to the patient or caregiver website.

CLINDAMYCIN Phosphate Topical Gel or Lotion (GREENSTONE LLC) Adverse Reactions

ADVERSE REACTIONS

In 18 clinical studies of various formulations of clindamycin phosphate using placebo vehicle and/or active comparator drugs as controls, patients experienced a number of treatment emergent adverse dermatologic events [see table below].

Number of Patients Reporting Events
Treatment Emergent Adverse EventSolution
n=553(%)
Gel
n=148(%)
Lotion
n=160(%)
*
not recorded
of 126 subjects
Burning62 (11)15 (10)17 (11)
Itching36 ( 7)15 (10)17 (11)
Burning/Itching60 (11)* ( – )* ( – )
Dryness105 (19)34 (23)29 (18)
Erythema86 (16)10 ( 7)22 (14)
Oiliness/Oily Skin8 ( 1)26 (18)12 (10)
Peeling61 (11)* ( – )11 ( 7)

Orally and parenterally administered clindamycin has been associated with severe colitis which may end fatally.

Cases of diarrhea, bloody diarrhea and colitis (including pseudomembranous colitis) have been reported as adverse reactions in patients treated with oral and parenteral formulations of clindamycin and rarely with topical clindamycin (see WARNINGS).

Abdominal pain, gastrointestinal disturbances, gram-negative folliculitis, eye pain and contact dermatitis have also been reported in association with the use of topical formulations of clindamycin.

Did you find an answer to your question? Yes No
Did you find an answer to your question? Yes No
Didn’t find what you were looking for? Contact us.
Report Adverse Event