Parenteral (IM or IV Administration)
Serious infections due to aerobic gram-positive cocci and the more susceptible anaerobes (NOT generally including Bacteroides fragilis, Peptococcus species and Clostridium species other than Clostridium perfringens):
600–1200 mg/day in 2, 3 or 4 equal doses.
More severe infections, particularly those due to proven or suspected Bacteroides fragilis, Peptococcus species, or Clostridium species other than Clostridium perfringens:
1200–2700 mg/day in 2, 3 or 4 equal doses.
For more serious infections, these doses may have to be increased. In life-threatening situations due to either aerobes or anaerobes these doses may be increased. Doses of as much as 4800 mg daily have been given intravenously to adults. See Dilution for IV use and IV Infusion Rates section below.
Single intramuscular injections of greater than 600 mg are not recommended.
Alternatively, drug may be administered in the form of a single rapid infusion of the first dose followed by continuous IV infusion as follows:
Table 2: Serum Clindamycin Levels Maintained, Rapid Infusion Rate and Maintenance Infusion RateTo maintain serum clindamycin levels | Rapid infusion rate | Maintenance infusion rate |
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Above 4 mcg/mL | 10 mg/min for 30 min | 0.75 mg/min |
Above 5 mcg/mL | 15 mg/min for 30 min | 1.00 mg/min |
Above 6 mcg/mL | 20 mg/min for 30 min | 1.25 mg/min |