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cisatracurium besylate
If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents.
Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.
cisatracurium besylate Quick Finder
Highlights
Indications and Usage
1 INDICATIONS AND USAGE
Cisatracurium Besylate Injection is indicated:
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- as an adjunct to general anesthesia to facilitate tracheal intubation in adults and in pediatric patients 1 month to 12 years of age...
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Dosage and Administration
2 DOSAGE AND ADMINISTRATION
2.1 Important Dosage and Administration Instructions
Risk of Medication Errors
Accidental...
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Dosage Forms and Strengths
3 DOSAGE FORMS AND STRENGTHS
Cisatracurium Besylate Injection, USP is available as a clear solution in the following strengths:
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- 10 mg of cisatracurium per 5 mL (2 mg/mL) in single-dose vials (equivalent...
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Contraindications
4 CONTRAINDICATIONS
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- Cisatracurium Besylate Injection is contraindicated in patients with known hypersensitivity to cisatracurium. Severe anaphylactic reactions to Cisatracurium Besylate Injection have been reported...
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Warnings and Precautions
5 WARNINGS AND PRECAUTIONS
5.1 Residual Paralysis
Cisatracurium Besylate Injection has been associated with residual paralysis. Patients with neuromuscular diseases (...
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Adverse Reactions
6 ADVERSE REACTIONS
6.1 Clinical Studies Experience
Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the...
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Drug Interactions
7 DRUG INTERACTIONS
7.1 Clinically Significant Drug Interactions
Table 4 displays clinically significant drug interactions with Cisatracurium Besylate Injection....
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Use in Specific Populations
8 USE IN SPECIFIC POPULATIONS
8.1 Pregnancy
Risk Summary
The 10 mL...
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Overdosage
10 OVERDOSAGE
Overdosage with neuromuscular blocking agents may result in neuromuscular blockade beyond the time needed for surgery and anesthesia. The primary treatment is maintenance of a patent airway and controlled...
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Description
11 DESCRIPTION
Cisatracurium besylate is a nondepolarizing skeletal neuromuscular blocker for intravenous administration. Compared to other neuromuscular blockers, it is intermediate in its onset and duration of action....
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Clinical Pharmacology
12 CLINICAL PHARMACOLOGY
12.1 Mechanism of Action
Cisatracurium besylate binds competitively to cholinergic receptors on the motor end-plate to antagonize the action...
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Nonclinical Toxicology
13 NONCLINICAL TOXICOLOGY
13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility
...
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Clinical Studies
14 CLINICAL STUDIES
14.1 Skeletal Muscle Relaxation for Intubation of Adult Patients
The efficacy of Cisatracurium Besylate Injection to provide skeletal muscle...
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How Supplied/Storage and Handling
16 HOW SUPPLIED/STORAGE AND HANDLING
Cisatracurium Besylate Injection, USP is a clear solution supplied as follows:
Cisatracurium Besylate Injection, USP, 2 mg cisatracurium per mL, is supplied in the following:
...
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Medication Guide
17 PATIENT COUNSELING INFORMATION
Hypersensitivity Reactions Including Anaphylaxis
Advise the caregiver and/or family that severe...
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Report Adverse Event
To report an adverse event related to Pfizer-BioNTech COVID-19 Vaccine (also known as COMIRNATY®, COVID-19 mRNA, Vaccine BNT162b2 or BNT162) or Pfizer COVID-19 Treatment (also known as PAXLOVID™ (nirmatrelvir tablets; ritonavir tablets)), and you are not part of a clinical trial* for this product, click the link below to submit your information:
*If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site.
If you cannot use the above website or would like to report an adverse event related to a different Pfizer product, please call Pfizer Safety at(800) 438-1985.
You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatchor by calling
(800)-332-1088.
(800)-332-1088.