Erectile Dysfunction of Vasculogenic, Psychogenic, or Mixed Etiology.
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- Initiate dosing with 2.5 mcg of CAVERJECT IMPULSE intracavernousally as recommended [see Dosage and Administration 2.4].
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- If there is a partial response at 2.5 mcg, administer another dose of 2.5 mcg within 1 hour.
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- During titration, no more than 2 doses should be given within a 24-hour period.
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- If additional titration is required, administer doses in increments of 5 to 10 mcg at least 24 hours apart.
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- The optimal dose should produce an erection suitable for intercourse that does not exceed a duration of 1 hour.
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- The patient must stay in the health care provider’s office until complete detumescence occurs.
Repeat the titration as necessary until the optimal dose is achieved. Doses greater than 60 mcg are not recommended.
Erectile Dysfunction of Pure Neurogenic Etiology (Spinal Cord Injury):
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- Initiate dosing with 1.25 mcg of alprostadil using CAVERJECT.
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- If there is a partial response, administer another dose of CAVERJECT of 1.25 mcg within 1 hour.
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- No more than 2 doses during initial titration should be given within a 24-hour period.
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- If additional titration is required, administer a dose of 5 mcg at least 24 hours later.
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- The optimal dose should produce an erection suitable for intercourse that does not exceed a duration of 1 hour.
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- The patient must stay in the health care provider’s office until complete detumescence occurs.
Repeat the titration as necessary until the optimal dose is achieved. Doses greater than 60 mcg are not recommended.
Maintenance Dosage for Patient Home Use:
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- Once the dose of CAVERJECT IMPULSE has been determined in the health care provider’s office, additional dose adjustment may be required after consultation with the health care provider. Adjust the dose in accordance with the titration guidelines described above.
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- The recommended frequency of injection is no more than 3 times weekly, with at least 24 hours between each dose.
Adjunct to the Diagnosis of Erectile Dysfunction
To diagnose erectile dysfunction (pharmacologic testing), inject CAVERJECT IMPULSE intracavernosally and monitor patients for the occurrence of an erection. Extensions of this testing are the use of CAVERJECT as an adjunct to laboratory investigations, such as duplex or Doppler imaging. For any of these tests, use a single dose of CAVERJECT IMPULSE that induces a rigid erection. Use the dose regimen for ‘Erectile Dysfunction of Vasculogenic, Psychogenic, or Mixed Etiology’ above.