CARBOCAINE Description

(mepivacaine Hydrochloride Injection, USP)

DESCRIPTION

Mepivacaine hydrochloride is 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl, monohydrochloride and has the following structural formula:

C15H22N2O • HCl

It is a white crystalline odorless powder, soluble in water, but very resistant to both acid and alkaline hydrolysis.

CARBOCAINE is a local anesthetic available as sterile isotonic solutions (clear, colorless) in concentrations of 1%, 1.5%, and 2% for injection via local infiltration, peripheral nerve block, and caudal and lumbar epidural blocks.

Mepivacaine hydrochloride is related chemically and pharmacologically to the amide-type local anesthetics. It contains an amide linkage between the aromatic nucleus and the amino group.

* In Water for Injection. The pH of the solution is adjusted between 4.5 and 6.8 with sodium hydroxide or hydrochloric acid.
Composition of Available Solutions*
	1% Single-Dose 30 mL Vial mg/mL	1% Multiple-Dose 50 mL Vial mg/mL	1.5% Single-Dose 30 mL Vial mg/mL	2% Single-Dose 20 mL Vial mg/mL	2% Multiple-Dose 50 mL Vial mg/mL
Mepivacaine hydrochloride	10	10	15	20	20
Sodium chloride	6.6	7	5.6	4.6	5
Potassium chloride	0.3		0.3	0.3
Calcium chloride	0.33		0.33	0.33
Methylparaben		1			1

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Description

DESCRIPTION

Mepivacaine hydrochloride is 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl, monohydrochloride and has the following structural formula:

C15H22N2O • HCl

It is a white crystalline odorless powder, soluble in water, but very resistant to both acid and alkaline hydrolysis.

Mepivacaine hydrochloride is related chemically and pharmacologically to the amide-type local anesthetics. It contains an amide linkage between the aromatic nucleus and the amino group.

* In Water for Injection. The pH of the solution is adjusted between 4.5 and 6.8 with sodium hydroxide or hydrochloric acid.
Composition of Available Solutions*
	1% Single-Dose 30 mL Vial mg/mL	1% Multiple-Dose 50 mL Vial mg/mL	1.5% Single-Dose 30 mL Vial mg/mL	2% Single-Dose 20 mL Vial mg/mL	2% Multiple-Dose 50 mL Vial mg/mL
Mepivacaine hydrochloride	10	10	15	20	20
Sodium chloride	6.6	7	5.6	4.6	5
Potassium chloride	0.3		0.3	0.3
Calcium chloride	0.33		0.33	0.33
Methylparaben		1			1

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