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CARBOCAINE Description (mepivacaine Hydrochloride Injection, USP)

DESCRIPTION

Mepivacaine hydrochloride is 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl, monohydrochloride and has the following structural formula:

structural formula carbocaine

                C15H22N2O • HCl

It is a white crystalline odorless powder, soluble in water, but very resistant to both acid and alkaline hydrolysis.

CARBOCAINE is a local anesthetic available as sterile isotonic solutions (clear, colorless) in concentrations of 1%, 1.5%, and 2% for injection via local infiltration, peripheral nerve block, and caudal and lumbar epidural blocks.

Mepivacaine hydrochloride is related chemically and pharmacologically to the amide-type local anesthetics. It contains an amide linkage between the aromatic nucleus and the amino group.

*
In Water for Injection.
The pH of the solution is adjusted between 4.5 and 6.8 with sodium hydroxide or hydrochloric acid.

Composition of Available Solutions*

1%

Single-Dose

30 mL Vial

mg/mL

1%

Multiple-Dose

50 mL Vial

mg/mL

1.5%

Single-Dose

30 mL Vial

mg/mL

2%

Single-Dose

20 mL Vial

mg/mL

2%

Multiple-Dose

50 mL Vial

mg/mL

Mepivacaine
hydrochloride

 
10

 
10

 
15

 
20

 

20

Sodium chloride

6.6

7

5.6

4.6

5

Potassium chloride

0.3

0.3

0.3

Calcium chloride

0.33

0.33

0.33

Methylparaben

1

1

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