6 ADVERSE REACTIONS
The following serious adverse reactions are also described elsewhere in the labeling:
- •
- End-Organ Damage due to Intravascular Ceftriaxone-Calcium Precipitates [see Warnings and Precautions (5.1)]
- •
- Hypotension, Bradycardia, Arrhythmias, and Syncope with Rapid Administration [see Warnings and Precautions (5.2)]
- •
- Arrhythmias with Concomitant Digoxin Use [see Warnings and Precautions (5.3)]
- •
- Tissue Necrosis and Calcinosis [see Warnings and Precautions (5.4)]
- •
- Aluminum toxicity [see Warnings and Precautions (5.5)]
The following adverse reactions have been identified in literature and postmarketing reports of calcium chloride. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure:
- •
- Nervous system disorders: Paraesthesia (upon rapid injection), calcium taste
- •
- General disorders and administration site conditions: Sense of oppression, sense of “heat wave”, local burning sensation, injection site extravasation, injection site reactions
- •
- Cardiovascular disorders: Peripheral vasodilatation, decreased blood pressure