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Bumetanide Injection, USP Description


Bumetanide is a loop diuretic, available in 4 mL and 10 mL vials for intravenous or intramuscular injection as a sterile solution. Each mL contains 0.25 mg bumetanide compounded with 0.85% sodium chloride and 0.4% ammonium acetate as buffers; 0.01% edetate disodium; 1% benzyl alcohol as preservative, and pH adjusted to approximately 7 with sodium hydroxide.

Chemically, bumetanide is 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid. It is a practically white powder, slightly soluble in water; soluble in alkaline solutions, having a calculated molecular weight of 364.42, and the following structural formula:

Structural Formula Bumetanide

Molecular Formula: C17H20N2O5S

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