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Bumetanide Injection, USP

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Bumetanide Injection, USP Quick Finder

WARNING

Bumetanide injection is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required, and dose and dosage schedule have to be...

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INDICATIONS AND USAGE

Bumetanide injection is indicated for the treatment of edema associated with congestive heart failure, hepatic and renal disease, including the nephrotic syndrome.

Almost equal diuretic response...

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DOSAGE AND ADMINISTRATION

Dosage should be individualized with careful monitoring of patient response.

Parenteral Administration:

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CONTRAINDICATIONS

Bumetanide is contraindicated in anuria. Although bumetanide can be used to induce diuresis in renal insufficiency, any marked increase in blood urea nitrogen or creatinine, or the development of oliguria...

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WARNINGS

1.
Volume and electrolyte depletion. The dose of bumetanide should be adjusted to the patient's needs. Excessive doses or too frequent administration can lead to profound water loss, electrolyte depletion,...
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ADVERSE REACTIONS

The most frequent clinical adverse reactions considered probably or possibly related to bumetanide are muscle cramps (seen in 1.1% of treated patients), dizziness (1.1%), hypotension (0.8%), headache (0.6...

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OVERDOSAGE

Overdosage can lead to acute profound water loss, volume and electrolyte depletion, dehydration, reduction of blood volume and circulatory collapse with a possibility of vascular thrombosis and embolism....

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DESCRIPTION

Bumetanide is a loop diuretic, available in 4 mL and 10 mL vials for intravenous or intramuscular injection as a sterile solution. Each mL contains 0.25 mg bumetanide compounded with 0.85% sodium chloride and 0.4...

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CLINICAL PHARMACOLOGY

Bumetanide is a loop diuretic with a rapid onset and short duration of action. Pharmacological and clinical studies have shown that 1 mg bumetanide has a diuretic potency equivalent to approximately 40...

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HOW SUPPLIED

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