BICILLIN® CR 900/300 (penicillin G benzathine, penicillin G procaine) | Pfizer Medical Information - US

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Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

BICILLIN® C-R 900/300 Quick Finder

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WARNING: NOT FOR INTRAVENOUS USE. DO NOT INJECT INTRAVENOUSLY OR ADMIX WITH OTHER INTRAVENOUS SOLUTIONS. THERE HAVE BEEN REPORTS OF INADVERTENT INTRAVENOUS ADMINISTRATION OF PENICILLIN G BENZATHINE WHICH HAS BEEN ASSOCIATED WITH...

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INDICATIONS AND USAGE

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bicillin C-R 900/300 and other antibacterial drugs, Bicillin C-R 900/300 should be used only to treat or prevent...

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DOSAGE AND ADMINISTRATION

Streptococcal Infections

Group A infections of the upper-respiratory tract, skin and soft-tissue infections, scarlet fever, and erysipelas:...

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CONTRAINDICATIONS

A previous hypersensitivity reaction to any penicillin or to procaine is a contraindication.

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WARNINGS

WARNING: NOT FOR INTRAVENOUS USE. DO NOT INJECT...

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ADVERSE REACTIONS

As with other penicillins, untoward reactions of the sensitivity phenomena are likely to occur, particularly in individuals who have previously demonstrated hypersensitivity to penicillins or in those with...

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OVERDOSAGE

Penicillin in overdosage has the potential to cause neuromuscular hyperirritability or convulsive seizures.

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DESCRIPTION

Bicillin C-R 900/300 (penicillin G benzathine and penicillin G procaine injectable suspension) contains the equivalent of 900,000 units of penicillin G as the benzathine and 300,000 units of penicillin G as the...

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CLINICAL PHARMACOLOGY

General

Penicillin G benzathine and penicillin G procaine have a low solubility and, thus, the drugs are slowly released from intramuscular...

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REFERENCES

1.: SHAW, E.: Transverse myelitis from injection of penicillin. Am. J. Dis. Child., 111:548, 1966.
2.: KNOWLES, J.: Accidental intra-arterial injection of penicillin....

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HOW SUPPLIED

Bicillin® C-R 900/300 (penicillin G benzathine and penicillin G procaine injectable suspension) is supplied in packages of 10 disposable syringes as follows:

2 mL size, containing...

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For deep IM injection only.

To reduce the development of drug-resistant...

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To report an adverse event related to a Pfizer product and you are not part of a clinical trial* for this product, click the link below to submit your information: Pfizer Safety Reporting Site

*If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site.

If you cannot use the above website to report an adverse event related to a Pfizer product, please call Pfizer Medical Information at (800) 438-1985.

FDA Medwatch

You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatchor by calling
(800)-332-1088.