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AZTREONAM (aztreonam for injection, USP)

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AZTREONAM Quick Finder

INDICATIONS AND USAGE

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Aztreonam for Injection, USP and other antibacterial drugs, aztreonam for injection should be used only to treat or...

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DOSAGE AND ADMINISTRATION

Dosage in Adult Patients

Aztreonam for Injection may be administered intravenously or by intramuscular injection. Dosage and route of...

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CONTRAINDICATIONS

This preparation is contraindicated in patients with known hypersensitivity to aztreonam or any other component in the formulation.

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WARNINGS

Both animal and human data suggest that aztreonam for injection is rarely cross-reactive with other beta-lactam antibiotics and weakly immunogenic. Treatment with aztreonam can result in hypersensitivity reactions...

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ADVERSE REACTIONS

Local reactions such as phlebitis/thrombophlebitis following intravenous administration, and discomfort/swelling at the injection site following intramuscular administration occurred at rates of...

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OVERDOSAGE

If necessary, aztreonam may be cleared from the serum by hemodialysis and/or peritoneal dialysis.

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DESCRIPTION

Aztreonam for Injection, USP contains the active ingredient aztreonam, a monobactam. It was originally isolated from Chromobacterium violaceum. It is a synthetic bactericidal...

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CLINICAL PHARMACOLOGY

Single 30-minute intravenous infusions of 500 mg, 1 g, and 2 g doses of aztreonam for injection in healthy subjects produced aztreonam peak serum levels of 54 mcg/mL, 90 mcg/mL, and 204 mcg/mL,...

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CLINICAL STUDIES

A total of 612 pediatric patients aged 1 month to 12 years were enrolled in uncontrolled clinical trials of aztreonam in the treatment of serious Gram-negative infections, including urinary tract, lower...

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HOW SUPPLIED

Aztreonam for Injection, USP single-dose vials are supplied as follows:

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Rx only

To reduce the development of drug-resistant bacteria and maintain the effectiveness of aztreonam for injection and other antibacterial...

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