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ATGAM® Drug Interactions (lymphocyte immune globulin, anti-thymocyte globulin [equine])


A potential pharmacodynamic interaction concerns the concomitant administration of ATGAM with corticosteroids and other immunosuppressants, which are associated with an increased susceptibility to bacterial, viral and fungal infections, as they inhibit the immune system. The severity of the infections such as septicemia may be masked and their clinical presentations may be atypical.

Monitor patients receiving ATGAM and immunosuppressive agents such as corticosteroids when the dose of corticosteroids and other immunosuppressants is being reduced, since this adjustment of dose may result in reduced immunosuppression and lead to development of previously masked reactions to ATGAM.

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