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aminocaproic acid injection, USP

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aminocaproic acid injection, USP Quick Finder

INDICATIONS AND USAGE

Aminocaproic Acid Injection, is useful in enhancing hemostasis when fibrinolysis contributes to bleeding. In life-threatening situations, fresh whole blood transfusions, fibrinogen infusions, and other...

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DOSAGE AND ADMINISTRATION

Intravenous

Aminocaproic Acid Injection, USP is administered by infusion, utilizing the usual compatible intravenous vehicles (e.g.,...

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CONTRAINDICATIONS

Aminocaproic acid should not be used when there is evidence of an active intravascular clotting process.

When there is uncertainty as to whether the cause of bleeding is primary fibrinolysis or...

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WARNINGS

In patients with upper urinary tract bleeding, aminocaproic acid administration has been known to cause intrarenal obstruction in the form of glomerular capillary thrombosis or clots in the renal pelvis and ureters...

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ADVERSE REACTIONS

Aminocaproic Acid Injection is generally well tolerated. The following adverse experiences have been reported:

General: Edema, headache, malaise.

Hypersensitivity Reactions: Allergic and...

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OVERDOSAGE

A few cases of acute overdosage with Aminocaproic Acid Injection administered intravenously have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure...

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DESCRIPTION

Aminocaproic Acid Injection, USP is a 6-aminohexanoic acid, which acts as an inhibitor of fibrinolysis.

Aminocaproic Acid is soluble in water, acid and alkaline solutions; it is sparingly soluble in...

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CLINICAL PHARMACOLOGY

The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity. In adults, oral...

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References

* Stefanini, M. and Dameshek, W.: The Hemorrhagic Disorder, Ed. 2, New York. Grune and Stratton, pp. 510-514, 1962.

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HOW SUPPLIED

Aminocaproic Acid Injection, USP is supplied in single-dose containers as follows:

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5 g/20 mL (250 mg/mL)

Plastic Fliptop Vial

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