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AMIDATE (etomidate injection, USP)

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AMIDATE Quick Finder

INDICATIONS AND USAGE

AMIDATE is indicated by intravenous injection for the induction of general anesthesia. When considering use of AMIDATE, the usefulness of its hemodynamic properties (see ...

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DOSAGE AND ADMINISTRATION

Do not administer unless solution is clear and container is undamaged. Discard unused portion (see

Premedication

AMIDATE is compatible with commonly...

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CONTRAINDICATIONS

AMIDATE is contraindicated in patients who have shown hypersensitivity to it.

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WARNINGS

INTRAVENOUS AMIDATE SHOULD BE ADMINISTERED ONLY BY PERSONS TRAINED IN THE ADMINISTRATION OF GENERAL ANESTHETICS AND IN THE MANAGEMENT OF COMPLICATIONS ENCOUNTERED DURING THE CONDUCT OF GENERAL ANESTHESIA.

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ADVERSE REACTIONS

The most frequent adverse reactions associated with use of intravenous AMIDATE are transient venous pain on injection and transient skeletal muscle movements, including myoclonus:

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OVERDOSAGE

Overdosage may occur from too rapid or repeated injections. Too rapid injection may be followed by a fall in blood pressure. No adverse cardiovascular or respiratory effects attributable to AMIDATE overdose have...

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DESCRIPTION

AMIDATE (Etomidate Injection, USP) is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0).

It is intended for the induction of...

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CLINICAL PHARMACOLOGY

Etomidate is a general anesthetic without analgesic activity. Intravenous injection of etomidate produces anesthesia characterized by a rapid onset of action, usually within one minute. Duration of...

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ANIMAL TOXICOLOGY AND/OR PHARMACOLOGY

Published studies in animals demonstrate that the use of anesthetic agents during the period of rapid brain growth or synaptogenesis results in widespread neuronal and oligodendrocyte...

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HOW SUPPLIED

AMIDATE™ (Etomidate Injection, USP) is supplied in single-dose containers as follows:

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For intravenous use

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