alfentanil injection, USP Indications and Usage | Pfizer Medical Information

1 INDICATIONS AND USAGE

Alfentanil injection is indicated:

as an analgesic adjunct given in incremental doses in the maintenance of anesthesia with barbiturate/nitrous oxide/oxygen.
as an analgesic administered by continuous infusion with nitrous oxide/oxygen in the maintenance of general anesthesia.
as a primary anesthetic agent for the induction of anesthesia in patients undergoing general surgery in which endotracheal intubation and mechanical ventilation are required.
as the analgesic component for monitored anesthesia care (MAC).

alfentanil injection, USP Quick Finder

Pfizer samples (for eligible HCPs)

Requests for samples of prescription medications can be made by contacting Pfizer for Professionals at 1-800-505-4426 or by visiting the PfizerPro website www.pfizerpro.com.
Report an adverse event or concern about the quality of a Pfizer product

To report an adverse event related to Pfizer-BioNTech COVID-19 Vaccine (also known as COMIRNATY®, COVID-19 mRNA, Vaccine BNT162b2 or BNT162) or Pfizer COVID-19 Treatment (also known as PAXLOVID™ (nirmatrelvir tablets; ritonavir tablets)), and you are not part of a clinical trial* for this product, click the link below to submit your information:
Pfizer Safety Reporting Site
*If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site.
If you cannot use the above website or would like to report an adverse event related to a different Pfizer product, please call Pfizer Safety at (800) 438-1985.
If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly by visiting www.fda.gov/medwatch or by calling (800)-332-1088.
Assistance programs (for eligible patients)

Pfizer RxPathways connects eligible patients to a range of assistance programs that offer insurance support, co-pay help, and medicines for free or at a savings. Patients and physicians can contact RxPathways at (866) 706-2400 or visit the website for more information on these programs www.pfizerrxpathways.com.
Resources

Show All Hide All

HIGHLIGHTS OF PRESCRIBING INFORMATION

These highlights do not include all the...

Did you find an answer to your question? Yes No

WARNING: ADDICTION, ABUSE, AND MISUSE

Addiction, Abuse, and Misuse

Alfentanil injection exposes patients and...

Did you find an answer to your question? Yes No

1 INDICATIONS AND USAGE

Alfentanil injection is indicated:

as an analgesic adjunct given in incremental doses in the maintenance of anesthesia with barbiturate/nitrous oxide/oxygen.
as an...

Did you find an answer to your question? Yes No

2 DOSAGE AND ADMINISTRATION

2.1 Important Dosage and Administration Instructions

Alfentanil injection should be administered only by persons specifically trained in...

Did you find an answer to your question? Yes No

3 DOSAGE FORMS AND STRENGTHS

Alfentanil Injection USP, for intravenous use (equivalent to 500 mcg/mL alfentanil base).

Did you find an answer to your question? Yes No

4 CONTRAINDICATIONS

Alfentanil injection is contraindicated in patients with:

Hypersensitivity to alfentanil (e.g., anaphylaxis) [see Adverse Reactions (6)]...

Did you find an answer to your question? Yes No

5 WARNINGS AND PRECAUTIONS

5.1 Addiction, Abuse, and Misuse

Alfentanil injection contains alfentanil, a Schedule II controlled substance. As an opioid, alfentanil...

Did you find an answer to your question? Yes No

6 ADVERSE REACTIONS

The following serious adverse reactions are described, or described in greater detail, in other sections:

Addiction, Abuse, and Misuse [see ...

Did you find an answer to your question? Yes No

7 DRUG INTERACTIONS

Table 2 includes clinically significant drug interactions with alfentanil injection.

Did you find an answer to your question? Yes No

8 USE IN SPECIFIC POPULATIONS

8.1 Pregnancy

Risk Summary

Prolonged use of opioid...

Did you find an answer to your question? Yes No

9 DRUG ABUSE AND DEPENDENCE

9.1 Controlled Substance

Alfentanil injection contains alfentanil, a Schedule II controlled substance.

...

Did you find an answer to your question? Yes No

10 OVERDOSAGE

Clinical Presentation

Acute overdose with alfentanil injection can be manifested by respiratory depression, somnolence...

Did you find an answer to your question? Yes No

11 DESCRIPTION

Alfentanil Injection, USP contains alfentanil, an opioid agonist, chemically designated as N- [1- [2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1- yl) ethyl]-4-(methoxymethyl)-4-piperidinyl]-N-phenylpropanamide...

Did you find an answer to your question? Yes No

12 CLINICAL PHARMACOLOGY

12.1 Mechanism of Action

Alfentanil injection is an opioid agonist. The principal actions of therapeutic value are analgesia and sedation....

Did you find an answer to your question? Yes No

13 NONCLINICAL TOXICOLOGY

13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility

...

Did you find an answer to your question? Yes No

16 HOW SUPPLIED/STORAGE AND HANDLING

HOW SUPPLIED

Alfentanil Injection, USP for intravenous use contains alfentanil hydrochloride equivalent to 500 mcg/mL of...

Did you find an answer to your question? Yes No

Logo

Distributed by
Hospira, Inc., Lake Forest, IL 60045 USA

LAB-1059-3.0

Did you find an answer to your question? Yes No

Didn’t find what you were looking for? Contact us.

MI Digital Assistant

Chat online with Pfizer Medical Information regarding your inquiry on a Pfizer medicine.

Call 800-438-1985^*

*Contact Medical Information.

Medical Inquiry

Submit a medical question for Pfizer prescription products.

Report Adverse Event

Pfizer Safety

To report an adverse event related to Pfizer-BioNTech COVID-19 Vaccine (also known as COMIRNATY®, COVID-19 mRNA, Vaccine BNT162b2 or BNT162) or Pfizer COVID-19 Treatment (also known as PAXLOVID™ (nirmatrelvir tablets; ritonavir tablets)), and you are not part of a clinical trial* for this product, click the link below to submit your information:

Pfizer Safety Reporting Site

*If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site.

If you cannot use the above website or would like to report an adverse event related to a different Pfizer product, please call Pfizer Safety at
(800) 438-1985.

FDA Medwatch

You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatchor by calling
(800)-332-1088.