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ALDACTAZIDE®(spironolactone, hydrochlorothiazide)

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ALDACTAZIDE® Quick Finder

INDICATIONS AND USAGE

Spironolactone, an ingredient of ALDACTAZIDE, has been shown to be a tumorigen in chronic toxicity studies in rats (see

ALDACTAZIDE is indicated for:...

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DOSAGE AND ADMINISTRATION

Optimal dosage should be established by individual titration of the components.

Edema in adults (congestive heart failure...

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CONTRAINDICATIONS

ALDACTAZIDE is contraindicated in patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, hypercalcemia, hyperkalemia, Addison's disease, and in patients who are...

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WARNINGS

Potassium supplementation, either in the form of medication or as a diet rich in potassium, should not ordinarily be given in association with ALDACTAZIDE therapy. Excessive potassium intake may cause hyperkalemia...

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ADVERSE REACTIONS

The following adverse reactions have been reported and, within each category (body system), are listed in order of decreasing severity.

...

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OVERDOSAGE

The oral LD50 of spironolactone is greater than 1000 mg/kg in mice, rats, and rabbits. The oral LD50 of hydrochlorothiazide is greater than 10 g/kg in both mice and...

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DESCRIPTION

ALDACTAZIDE oral tablets contain:

spironolactone . . . . . . . . . . . . . . . . . . . . 25 mg
hydrochlorothiazide . . . . . . . . . . . . . . . . 25 mg

or

spironolactone...

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ACTIONS / CLINICAL PHARMACOLOGY

Mechanism of action

ALDACTAZIDE is a combination of two diuretic agents with different but complementary mechanisms and sites of action...

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HOW SUPPLIED

ALDACTAZIDE tablets containing 25 mg of spironolactone (ALDACTONE) and 25 mg of hydrochlorothiazide are round, tan, film coated, with SEARLE and 1011 debossed on one side and ALDACTAZIDE and 25 on the other side...

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Pfizer Logo

LAB-0233-15.0
Revised: March 2021

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