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Adenosine Injection is indicated as an adjunct to thallium-201 myocardial perfusion scintigraphy in patients unable to exercise adequately.
The recommended adenosine injection dose is 0.14 mg/kg/min infused over six minutes (total dose of 0.84 mg/kg) (Table 1).
Adenosine Injection is supplied as 20 mL and 30 mL single-dose vials containing a sterile, nonpyrogenic, clear solution of adenosine 3mg/mL.
Adenosine injection is contraindicated in patients with:
Fatal and nonfatal cardiac arrest, sustained ventricular...
The following adverse reactions are discussed in more detail in other sections of the prescribing information:
Animal reproduction studies have not been conducted with adenosine; nor have studies been performed in pregnant women....
The half-life of adenosine is less than 10 seconds and adverse reactions of adenosine injection usually resolve quickly when the infusion is discontinued, although delayed or persistent reactions have been...
Adenosine is an endogenous nucleoside and is chemically described as 6-amino-9-beta-D-ribofuranosyl-9-H-purine. Adenosine has the following structural formula:
Adenosine causes cardiac vasodilation which increases cardiac blood flow. Adenosine is thought to exert its...
Studies in animals have not been performed to evaluate adenosine's carcinogenic...
In two crossover comparative studies involving 319 subjects who could exercise (including 106 healthy volunteers and 213 patients with known or suspected coronary disease), adenosine injection and...
Adenosine Injection, USP is supplied as 20 mL and 30 mL vials of sterile, nonpyrogenic, preservative-free, solution in normal saline:
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