ACCUPRIL® Description (quinapril HCl) | Pfizer Medical Information

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DESCRIPTION

ACCUPRIL® is the hydrochloride salt of quinapril, the ethyl ester of a non-sulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, quinaprilat.

Quinapril hydrochloride is chemically described as [3S-[2[R*(R*)], 3R*]]-2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, monohydrochloride. Its empirical formula is C25H30N2O5 ∙HCl and its structural formula is:

M.W.=474.98

Quinapril hydrochloride is a white to off-white amorphous powder that is freely soluble in aqueous solvents.

ACCUPRIL tablets contain 5 mg (equivalent to 5.416 mg Quinapril Hydrochloride), 10 mg (equivalent to 10.832 mg Quinapril Hydrochloride), 20 mg (equivalent to 21.664 mg Quinapril Hydrochloride), or 40 mg (equivalent to 43.328 mg Quinapril Hydrochloride) of quinapril for oral administration. Each tablet also contains candelilla wax, crospovidone, gelatin, lactose, magnesium carbonate, magnesium stearate, synthetic red iron oxide, and titanium dioxide.

If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents.

Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

ACCUPRIL® Quick Finder

Availability

Pfizer is experiencing a supply shortage of Accupril because of manufacturing disruptions. While Pfizer is managing this situation with urgency, at this time, we are unable to confirm a date when the situation will be resolved.

We understand and regret the challenges that this situation poses to patients. Pfizer fully realizes the importance of this medicine to patients. Ensuring continuity of the supply of our medicines is paramount. Until the Accupril shortage is resolved, patients will need to consult with their healthcare professional to choose an alternate treatment option.

Please refer to the full Prescribing Information on important treatment considerations for Accupril via the following link. In the event this link does not work, please access the product’s approved Prescribing Information at www.pfizer.com/products.
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