calcium chloride injection, USP - ANYSYR Highlights

HIGHLIGHTS OF PRESCRIBING INFORMATION

These highlights do not include all the information needed to use 10% CALCIUM CHLORIDE INJECTION safely and effectively. See full prescribing information for 10% CALCIUM CHLORIDE INJECTION.

CALCIUM CHLORIDE injection, for intravenous use only
Initial U.S. Approval: 1938

INDICATIONS AND USAGE

Calcium Chloride Injection is a form of calcium indicated for the treatment of adult and pediatric and patients with acute symptomatic hypocalcemia. (1)

Limitations of Use:

The safety and effectiveness of Calcium Chloride Injection for long-term use has not been established.

DOSAGE AND ADMINISTRATION

Administer Calcium Chloride Injection by slow intravenous infusion (not to exceed 1 mL/minute), in a central or deep vein. (2.1)
Do not use intramuscularly or subcutaneously. (2.1)
Do not administer unless solution is clear and seal is intact. (2.1)
Stop the administration if the patient complains of any administration-related discomfort, it may be resumed when symptoms disappear. (2.1)
The recommended adult dose is from 200 mg to 1,000 mg. (2.2)
The recommended pediatric dose is from 2.7 to 5 mg/kg of calcium chloride. (2.2)
Repeated injections may be required because of rapid calcium excretion. (2.2)
See the full prescribing information for the recommended starting dose in patients with renal impairment. (2.3)
Do not mix Calcium Chloride Injection with ceftriaxone or administer these products simultaneously via a Y-site because concurrent use can lead to the formation of ceftriaxone-calcium precipitates. (2.4)

DOSAGE FORMS AND STRENGTHS

Calcium Chloride Injection, USP (single-dose) is supplied as: (3)

10% (1,000 mg/10 mL) (100 mg/mL) in an Ansyr Plastic Syringe
10% (1,000 mg/10 mL) (100 mg/mL) in a LifeShield Abboject Glass Syringe

The 100 mg/mL concentration represents 27 mg or 1.4 mEq of elemental calcium per mL of solution. (3)

CONTRAINDICATIONS

Calcium Chloride Injection is contraindicated in:

Patients with ventricular fibrillation. (4)
Patients with asystole and electromechanical dissociation. (4)
Newborns (up to 28 days of age) if they require (or are expected to require) ceftriaxone intravenous treatment, regardless of whether these products would be received at different times or through separate intravenous lines. (4, 5.1)

WARNINGS AND PRECAUTIONS

End-Organ Damage due to Intravascular Ceftriaxone-Calcium Precipitates: Calcium Chloride Injection is contraindicated in newborns (up to 28 days of age) if they require (or are expected to require) ceftriaxone intravenous treatment. In patients older than 28 days of age, do not mix or administer simultaneously with ceftriaxone intravenous solutions, even via different infusion lines or at different infusion sites as it can lead to precipitation of ceftriaxone-calcium. (5.1)
Hypotension, Bradycardia, Arrhythmias, and Syncope with Rapid Administration: Too rapid an injection exceeding 1 mL/minute may lead to hypotension and syncope. (2.1, 5.2)
Arrhythmias with Concomitant Digoxin Use: Avoid use of Calcium Chloride Injection in patients receiving digoxin. Closely monitor ECG and calcium levels if concomitant therapy is necessary. (5.3, 7.1)
Tissue Necrosis and Calcinosis: Administer Calcium Chloride Injection slowly through a small needle into a large vein to minimize the risk of tissue necrosis, ulceration and calcinosis. Avoid extravasation or accidental injection into perivascular tissues. Immediately discontinue administration should perivascular infiltration occur. (2.1, 5.4)
Aluminum Toxicity: Risk of toxicity with prolonged administration if kidney function is impaired. Premature neonates are particularly at risk. When prescribing Calcium Chloride Injection in patients receiving parenteral nutrition solutions, limit the total daily patient exposure to aluminum to no more than 5 mcg/kg/day. (5.5)

ADVERSE REACTIONS

Adverse reactions have included paraesthesia (upon rapid injection), calcium taste, sense of oppression, sense of “heat wave”, local burning sensation, injection site extravasation, injection site reactions, peripheral vasodilatation, and decreased blood pressure. (6)

To report SUSPECTED ADVERSE REACTIONS, contact Pfizer Inc. at 1-800-438-1985 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

DRUG INTERACTIONS

Digoxin: Avoid concomitant use with Calcium Chloride Injection. If concomitant use is unavoidable, monitor ECG closely during administration of Calcium Chloride Injection. (5.3, 7.1)
Calcium Channel Blockers: Avoid concomitant use with Calcium Chloride Injection. If concomitant use is unavoidable, monitor blood pressure closely during administration of Calcium Chloride Injection. (7.2)
Drugs That Increase the Risk of Hypercalcemia: Increase the frequency of calcium concentration monitoring in patients taking Calcium Chloride Injection concomitantly with other drugs that increase the risk of hypercalcemia. (7.3)

See 17 for PATIENT COUNSELING INFORMATION.

Revised: 5/2023

Find calcium chloride injection, USP - ANYSYR medical information:

Find calcium chloride injection, USP - ANYSYR medical information:

Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

calcium chloride injection, USP - ANYSYR Quick Finder

Prescribing Information
Download Prescribing Information

Health Professional Information

Highlights

HIGHLIGHTS OF PRESCRIBING INFORMATION

These highlights do not include all the information needed to use 10% CALCIUM CHLORIDE INJECTION safely and effectively. See full prescribing information for 10% CALCIUM CHLORIDE INJECTION.

CALCIUM CHLORIDE injection, for intravenous use only
Initial U.S. Approval: 1938

INDICATIONS AND USAGE

Calcium Chloride Injection is a form of calcium indicated for the treatment of adult and pediatric and patients with acute symptomatic hypocalcemia. (1)

Limitations of Use:

The safety and effectiveness of Calcium Chloride Injection for long-term use has not been established.

DOSAGE AND ADMINISTRATION

Administer Calcium Chloride Injection by slow intravenous infusion (not to exceed 1 mL/minute), in a central or deep vein. (2.1)
Do not use intramuscularly or subcutaneously. (2.1)
Do not administer unless solution is clear and seal is intact. (2.1)
Stop the administration if the patient complains of any administration-related discomfort, it may be resumed when symptoms disappear. (2.1)
The recommended adult dose is from 200 mg to 1,000 mg. (2.2)
The recommended pediatric dose is from 2.7 to 5 mg/kg of calcium chloride. (2.2)
Repeated injections may be required because of rapid calcium excretion. (2.2)
See the full prescribing information for the recommended starting dose in patients with renal impairment. (2.3)
Do not mix Calcium Chloride Injection with ceftriaxone or administer these products simultaneously via a Y-site because concurrent use can lead to the formation of ceftriaxone-calcium precipitates. (2.4)

DOSAGE FORMS AND STRENGTHS

Calcium Chloride Injection, USP (single-dose) is supplied as: (3)

10% (1,000 mg/10 mL) (100 mg/mL) in an Ansyr Plastic Syringe
10% (1,000 mg/10 mL) (100 mg/mL) in a LifeShield Abboject Glass Syringe

The 100 mg/mL concentration represents 27 mg or 1.4 mEq of elemental calcium per mL of solution. (3)

CONTRAINDICATIONS

Calcium Chloride Injection is contraindicated in:

Patients with ventricular fibrillation. (4)
Patients with asystole and electromechanical dissociation. (4)
Newborns (up to 28 days of age) if they require (or are expected to require) ceftriaxone intravenous treatment, regardless of whether these products would be received at different times or through separate intravenous lines. (4, 5.1)

WARNINGS AND PRECAUTIONS

End-Organ Damage due to Intravascular Ceftriaxone-Calcium Precipitates: Calcium Chloride Injection is contraindicated in newborns (up to 28 days of age) if they require (or are expected to require) ceftriaxone intravenous treatment. In patients older than 28 days of age, do not mix or administer simultaneously with ceftriaxone intravenous solutions, even via different infusion lines or at different infusion sites as it can lead to precipitation of ceftriaxone-calcium. (5.1)
Hypotension, Bradycardia, Arrhythmias, and Syncope with Rapid Administration: Too rapid an injection exceeding 1 mL/minute may lead to hypotension and syncope. (2.1, 5.2)
Arrhythmias with Concomitant Digoxin Use: Avoid use of Calcium Chloride Injection in patients receiving digoxin. Closely monitor ECG and calcium levels if concomitant therapy is necessary. (5.3, 7.1)
Tissue Necrosis and Calcinosis: Administer Calcium Chloride Injection slowly through a small needle into a large vein to minimize the risk of tissue necrosis, ulceration and calcinosis. Avoid extravasation or accidental injection into perivascular tissues. Immediately discontinue administration should perivascular infiltration occur. (2.1, 5.4)
Aluminum Toxicity: Risk of toxicity with prolonged administration if kidney function is impaired. Premature neonates are particularly at risk. When prescribing Calcium Chloride Injection in patients receiving parenteral nutrition solutions, limit the total daily patient exposure to aluminum to no more than 5 mcg/kg/day. (5.5)

ADVERSE REACTIONS

Adverse reactions have included paraesthesia (upon rapid injection), calcium taste, sense of oppression, sense of “heat wave”, local burning sensation, injection site extravasation, injection site reactions, peripheral vasodilatation, and decreased blood pressure. (6)

To report SUSPECTED ADVERSE REACTIONS, contact Pfizer Inc. at 1-800-438-1985 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

DRUG INTERACTIONS

Digoxin: Avoid concomitant use with Calcium Chloride Injection. If concomitant use is unavoidable, monitor ECG closely during administration of Calcium Chloride Injection. (5.3, 7.1)
Calcium Channel Blockers: Avoid concomitant use with Calcium Chloride Injection. If concomitant use is unavoidable, monitor blood pressure closely during administration of Calcium Chloride Injection. (7.2)
Drugs That Increase the Risk of Hypercalcemia: Increase the frequency of calcium concentration monitoring in patients taking Calcium Chloride Injection concomitantly with other drugs that increase the risk of hypercalcemia. (7.3)

See 17 for PATIENT COUNSELING INFORMATION.

Revised: 5/2023

Medication Guide

Health Professional Information

{{section_name_patient}}

{{section_body_html_patient}}

Resources

Didn’t find what you were looking for? Contact us.

MI Digital Assistant

Chat online with Pfizer Medical Information regarding your inquiry on a Pfizer medicine.

Call 800-438-1985*

*Speak with a Pfizer Medical Information Professional regarding your medical inquiry. Available 9AM-5PM ET Monday to Friday; excluding holidays.

Medical Inquiry

Submit a medical question for Pfizer prescription products.

Report Adverse Event

Pfizer Safety

To report an adverse event related to the Pfizer-BioNTech COVID-19 Vaccine, and you are not part of a clinical trial* for this product, click the link below to submit your information:

Pfizer Safety Reporting Site

*If you are involved in a clinical trial for this product, adverse events should be reported to your coordinating study site.

If you cannot use the above website, or would like to report an adverse event related to a different Pfizer product, please call Pfizer Safety at (800) 438-1985.

FDA Medwatch

You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatch or call (800) 822-7967.