ANTIVENIN® Highlights

(micrurus fulvius)

HIGHLIGHTS OF PRESCRIBING INFORMATION

These highlights do not include all the information needed to use North American Coral Snake Antivenin (Equine) safely and effectively. See full prescribing information for North American Coral Snake Antivenin (Equine).

North American Coral Snake Antivenin (Equine)
Lyophilized Powder for Solution for Intravenous Injection
Initial U.S. Approval: 1967

INDICATIONS AND USAGE

North American Coral Snake Antivenin (Equine) is a horse-derived antivenin indicated for the treatment of envenomation caused by North American coral snakes - Micrurus. (1)

DOSAGE AND ADMINISTRATION

For intravenous use only.

  • In adults and adolescents, the dose may vary from 3 to 5 vials, depending on the response to treatment. (2.1)
  • In small children, the dose may be decreased, depending on the response to treatment. (2.1)
  • Contents of each reconstituted vial can neutralize approximately 250 mouse (Lethal Dose) LD50 or approximately 2 mg of M. fulvius venom. (2.1)
  • Infuse the first 1 or 2 mL over a 3- to 5-minute period, observing for allergic reaction. If tolerated, administer the rest of the dose at the rate that is comfortable for the patient based on body weight and general condition. Do not exceed 4 mL per minute for children. (2.2)

DOSAGE FORMS AND STRENGTHS

Lyophilized powder in single use vial for reconstitution for injection. (3)

CONTRAINDICATIONS

  • Do not administer North American Coral Snake Antivenin (Equine) prophylactically to asymptomatic patients. (4)
  • Do not use in patients with a known history of hypersensitivity to horse serum unless the benefits outweigh the risks and appropriate management for anaphylactic reactions is readily available. (4)

WARNINGS AND PRECAUTIONS

Patients sensitive to North American Coral Snake Antivenin (Equine) or horse serum may develop anaphylaxis. Prior to intravenous North American Coral Snake Antivenin (Equine) administration consider performing a proper skin test and modify therapy if indicated. (5.1)

ADVERSE REACTIONS

Adverse reactions may include anaphylaxis and serum sickness, vomiting, and abdominal pain. (6)


To report SUSPECTED ADVERSE REACTIONS, contact Pfizer, Inc. at 1-800-438-1985 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

See 17 for PATIENT COUNSELING INFORMATION.

Revised: 7/2019

Find ANTIVENIN® medical information:

Find ANTIVENIN® medical information:

Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

ANTIVENIN® Quick Finder

Prescribing Information
Download Prescribing Information

Health Professional Information

Highlights

HIGHLIGHTS OF PRESCRIBING INFORMATION

These highlights do not include all the information needed to use North American Coral Snake Antivenin (Equine) safely and effectively. See full prescribing information for North American Coral Snake Antivenin (Equine).

North American Coral Snake Antivenin (Equine)
Lyophilized Powder for Solution for Intravenous Injection
Initial U.S. Approval: 1967

INDICATIONS AND USAGE

North American Coral Snake Antivenin (Equine) is a horse-derived antivenin indicated for the treatment of envenomation caused by North American coral snakes - Micrurus. (1)

DOSAGE AND ADMINISTRATION

For intravenous use only.

  • In adults and adolescents, the dose may vary from 3 to 5 vials, depending on the response to treatment. (2.1)
  • In small children, the dose may be decreased, depending on the response to treatment. (2.1)
  • Contents of each reconstituted vial can neutralize approximately 250 mouse (Lethal Dose) LD50 or approximately 2 mg of M. fulvius venom. (2.1)
  • Infuse the first 1 or 2 mL over a 3- to 5-minute period, observing for allergic reaction. If tolerated, administer the rest of the dose at the rate that is comfortable for the patient based on body weight and general condition. Do not exceed 4 mL per minute for children. (2.2)

DOSAGE FORMS AND STRENGTHS

Lyophilized powder in single use vial for reconstitution for injection. (3)

CONTRAINDICATIONS

  • Do not administer North American Coral Snake Antivenin (Equine) prophylactically to asymptomatic patients. (4)
  • Do not use in patients with a known history of hypersensitivity to horse serum unless the benefits outweigh the risks and appropriate management for anaphylactic reactions is readily available. (4)

WARNINGS AND PRECAUTIONS

Patients sensitive to North American Coral Snake Antivenin (Equine) or horse serum may develop anaphylaxis. Prior to intravenous North American Coral Snake Antivenin (Equine) administration consider performing a proper skin test and modify therapy if indicated. (5.1)

ADVERSE REACTIONS

Adverse reactions may include anaphylaxis and serum sickness, vomiting, and abdominal pain. (6)


To report SUSPECTED ADVERSE REACTIONS, contact Pfizer, Inc. at 1-800-438-1985 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

See 17 for PATIENT COUNSELING INFORMATION.

Revised: 7/2019

Medication Guide

Health Professional Information

{{section_name_patient}}

{{section_body_html_patient}}

Resources

Didn’t find what you were looking for? Contact us.

MI Digital Assistant

Chat online with Pfizer Medical Information regarding your inquiry on a Pfizer medicine.

Call 800-438-1985*

*Contact Medical Information. 8AM-9PM ET Monday to Friday; excluding holidays.

Medical Inquiry

Submit a medical question for Pfizer prescription products.

Report Adverse Event

Pfizer Safety

To report an adverse event related to the Pfizer-BioNTech COVID-19 Vaccine, and you are not part of a clinical trial* for this product, click the link below to submit your information:

Pfizer Safety Reporting Site

*If you are involved in a clinical trial for this product, adverse events should be reported to your coordinating study site.

If you cannot use the above website, or would like to report an adverse event related to a different Pfizer product, please call Pfizer Safety at (800) 438-1985.

FDA Medwatch

You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatch or call (800) 822-7967.